目的：优化金银花提取液的醇沉工艺，规范清开灵注射液中金银花提取液的生产，减少批次间差异。方法：采用正交试验，以绿原酸和木犀草苷的含量为指标，并采用多指标综合评分法处理数据，优化醇沉工艺中加醇时的药液温度、搅拌速度和加醇速度3 个因素。结果：金银花提取液的最佳醇沉工艺为加醇时药液温度为20℃，搅拌速度240 rpm，加醇速度1 倍生药量/min。结论：优化的醇沉工艺稳定可行。
This study was aimed to optimize the alcohol precipitation techniques for honeysuckle extract in order to standardize the production of honeysuckle extract of Qingkailing Injection and reduce the differences among batches.The orthogonal test was applied in this study. The content of chlorogenic acid and galuteolin were taken as comprehensive indicators. Multi-index comprehensive scoring method was used in the data analysis. Three influencing factors, which were the fluid temperature, the stirring speed and the speed of adding alcohol, were optimized in the alcohol precipitation techniques. The results showed that the optimal alcohol precipitation techniques were when the fluid temperature was 20℃, the stirring speed was 240 rpm and the speed of adding alcohol was one time of the material per minute. It was concluded that the optimized alcohol precipitation process was stable and feasible.