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橘红痰咳液止咳化痰平喘抗炎作用的药效学研究
Pharmacodynamics Research on Antitussive, Expectorant, Antiasthmatic And Antiinflammatory Effect of Ju-Hong Tan-Ke Liquid
  
DOI:
中文关键词:  关键词:橘红痰咳液 止咳 化痰 平喘 抗炎 药效学研究
英文关键词:Keywords: Ju-Hong Tan-Ke liquid, antitussive, expectorant, antiasthmatic, anti-inflammatory, pharmacodynamics research
基金项目:
作者单位
王艳慧,黄洁文,江 晓,吴舒楹,连林生 广州市香雪制药股份有限公司 广州 510663 
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中文摘要:
      摘 要:目的:研究橘红痰咳液的止咳,化痰,平喘和抗炎的药效作用。方法:采用小鼠氨水引咳法和豚鼠枸橼酸引咳法观察止咳作用;用小鼠酚红排泌法,大鼠毛细玻管排痰法及对家兔气管纤毛运动影响实验观察化痰作用;用致敏原致大鼠哮喘实验观察平喘作用;用小鼠腹腔毛细血管通透性实验和二甲苯致小鼠耳廓肿胀实验观察抗炎作用。结果:橘红痰咳液能抑制呼吸道感受器的高敏感性而引起的反射性咳嗽,促进呼吸道黏膜黏液的分泌,增加痰液的排出量,促进气管纤毛运动使痰液排放更加顺利,能降低支气管的反应性,延长实验动物的哮喘潜伏期,抑制毛细血管通透性增加,减轻小鼠耳廓肿胀度。结论:橘红痰咳液能抑制呼吸道感受器的高敏感性而引起的反射性咳嗽,为外周性镇咳而非中枢性镇咳,具有显著的止咳,化痰,平喘和抗炎作用,并且其止咳,化痰,平喘及抗炎防治作用优于或等同于阳性化学对照药。
英文摘要:
      Abstract: This study was aimed to investigate the antitussive, expectorant, antiasthmatic and anti-inflammatory effect of Ju-Hong Tan-Ke (JHTK) liquid. The methods of cough induced by ammonia in mice and cough induced by citric acid in guinea pigs were used to observe the antitussive effects. The mouse phenolsulfonphthalein excretion method, rat capillary expectoration method and the rabbit tracheal cilia movement influence experiment were used to observe the expectorant effect. An experiment of allergen induced rats’ asthma was used to observe the antiasthmatic effects. The anti-inflammatory effect was observed by mouse peritoneal capillary permeability test and xylene induced ear swelling in mice. The results showed that JHTK liquid could inhibit cough induced by ammonia in mice, decrease the frequency of cough induced by citric acid in guinea pig and prolong the latent period of cough. The medicine could also obviously increase phenol red output of trachea in mice, promote expectoration in rats, accelerate the movement of cilium of tracheal transparently and prolong the latent period of asthma induced by allergens in rats, inhibit capillary permeability and lighten ear edema in mouse model. It was concluded that JHTK liquid could inhibit the reflex cough caused by hypersensitivity of airway sensor. It is peripheral antitussive rather than central antitussive, which has significant antitussive, expectorant, antiasthmatic and anti-inflammatory effects. Its efficacy is superior or equivalent to positive chemical control medicine.
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