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开心解郁方对抑郁模型大鼠行为学与血清炎性细胞因子的影响
Effect of Kai-Xin Jie-Yu Prescription on Behavior And Serum Inflammatory Cytokines in Rat Model of Depression
  
DOI:
中文关键词:  关键词: 开心解郁方 抑郁症 炎性细胞因子 慢性不可预知温和应激行为学
英文关键词:Keywords: Kai-Xin Jie-Yu prescription, depression, inflammatory cytokines, chronic unpredictable mild stress and stress behavior
基金项目:
作者单位
马 丽1,张 颖1,潘菊华1,王彦云1,孙梦云1,黄世敬 中国中医科学院广安门医院 北京 100053 
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中文摘要:
      摘 要:目的:探讨开心解郁方对抑郁模型大鼠抑郁行为及其外周炎性细胞因子表达水平的影响。方法:选用SD雄性大鼠,根据糖水偏好与体重分为正常组,模型组,中药组,采用慢性不可预知温和应激联合孤养6周的方法建立大鼠抑郁症模型,记录体重,行糖水偏好,强迫游泳试验评价大鼠的抑郁状态,通过酶联免疫吸附法检测大鼠血清中白细胞介素(IL)-1β,IL-2,IL-6,肿瘤坏死因子(TNF)-α浓度变化。结果:与正常组比较,模型组大鼠体重,糖水偏好与饮水总量显著降低,强迫游泳不动时显著延长,血清IL-1β,IL-2,IL-6,TNF-α表达水平显著升高;中药组大鼠体重与模型组比较无差异,糖水偏好与饮水总量显著升高,不动时间缩短,血清IL-1β,IL-2,IL-6,TNF-α表达水平显著降低。结论:开心解郁方能改善抑郁症模型大鼠的抑郁症状,可能与其调节血清炎性细胞因子的表达水平相关。
英文摘要:
      Abstract: This study was aimed to explore the antidepressant effect of Kai-Xin Jie-Yu (KXJY) prescription on depressive model of rats, and to explore the level of inflammatory cytokines in peripheral blood. According to sucrose preference and weight, male SD rats were randomly divided into the normal group, model group and traditional Chinese medicine (TCM) group. The model of depression was established by chronic unpredictable mild stress and separation for 6 weeks. Body weight, sucrose preference and forced swimming test were used to evaluate the depressive state. The levels of IL-1β, IL-2, IL-6 and TNF-α in the serum of rats were measured by ELISA. The results showed that compared with the normal group, the weight, sucrose preference and total drinking water of rat model group were significantly reduced. The immobility time of forced swimming was significantly prolonged. The level of IL-1β, IL-2, IL-6 and TNF-α expression in serum was significantly increased. There was no significant difference between the body weight of rats in the model group and TCM group. The total amount of drinking water and sucrose preference were significantly increased. The immobility time of forced swimming was reduced. Levels of IL-1β, IL-2, IL-6 and TNF-α expression were decreased significantly. It was concluded that KXJY prescription can improve depression symptoms in depression model of rats. It may be related to regulate the expression level of serum inflammatory cytokines.
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