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维药阿里红多糖对小鼠抗氧化能力及运动免疫抑制的影响研究
Effect of Inhibition of Uygur Fomes Officinalis Polysaccharides on Antioxidant Capacity And Exercise Immunity
  
DOI:
中文关键词:  关键词:维药阿里红多糖 运动疲劳 自由基 抗氧化 运动免疫抑制
英文关键词:Keywords: Uygur Fomes officinalis polysaccharides, sports fatigue, free radical, antioxidant, exercise immune suppression
基金项目:
作者单位
孔海军1,黄 玲2,王凤华1* 1.新疆师范大学体育学院运动生物化学实验室 乌鲁木齐 8300542.济南艾迪康医学检验中心 济南 250013 
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中文摘要:
      摘 要:目的:探讨维药阿里红多糖(FoP)的抗运动疲劳及运动免疫抑制作用,为维药阿里红作为天然抗氧化剂及免疫调节剂的开发利用提供实验依据。方法:通过递增负荷跑台运动建立长期运动疲劳及运动免疫抑制模型,不同剂量FoP作用于实验动物,将实验动物随机分为阳性对照组、阴性对照组、低剂量FoP(20 mg?kg-1)+运动组、中剂量FoP(40 mg?kg-1)+运动组、高剂量FoP(80 mg?kg-1)+运动组,每周灌胃6d,共8w,灌胃期间进行递增负荷跑台运动。8w后处死取材,试剂盒检测丙二醛(MDA)、超氧化物歧化酶(SOD)、血红蛋白(HB)、肌酸激酶(CK)水平,RT-PCR检测IL-4mRNA、INF-γ mRNA相对表达量。结果:与阳性对照组比较,FoP可以显著提高小鼠HB水平,FoP各剂量组血清CK水平出现显著下降;与阳性对照组比较,FoP组可显著消除MDA,FoP各剂量组间无显著差异;FoP各剂量组及阴性对照组血清SOD含量显著高于阳性对照组;FoP各剂量组IL-4 mRNA/INF-γmRNA比值基本处于平衡状态。结论:维药阿里红多糖可以有效促进机体疲劳恢复,加快自由基的清除,并显著改善机体的抗氧化能力及免疫状态。
英文摘要:
      Abstract: This study was aimed to investigate the effects of Fomes officinalis polysaccharides (FoP) on exercise-induced fatigue and exercise immune suppression in mice with FoP induced by exercise fatigue and unbalanced exercise immunity. Through treadmill exercise, the long-term exercise immune suppression model fatigue was established. Different doses of FoP were used in the animal experiment. The experimental animal were randomly divided into the positive control group, negative control group, low dose FoP (20 mg?kg-1) + exercise group, middle dose FoP (40 mg?kg-1) + exercise group, and the high dose FoP (80 mg?kg-1) + exercise group. The intragastric administration was given 6 days per week for 8 weeks. Treadmill exercise was administered during these 8 weeks. After 8 weeks, the samples were sacrificed. The levels of malondialdehyde (MDA), superoxide dismutase (SOD), hemoglobin (HB) and creatine kinase (CK) were detected by kit. And the relative expression of IL-4mRNA, INF-γ mRNA was detected by RT-PCR. The results showed that compared with the positive control group, FoP can significantly improve the level of HB in mice, the level of serum CK in each FoP dose group was significantly decreased; compared with the positive control group, FoP group can significantly eliminate MDA with no significant difference among different FoP dose groups. The contents of SOD in serum of different dose FoP group and the negative control group were significantly higher than that of the positive control group. The IL-4 mRNA / INF-γ mRNA ratio of different dose FoP group were in basic equilibrium. It was concluded that Uygur FoP can effectively promote the body fatigue recovery, accelerate the clearance of free radicals, and improve the antioxidant ability and immune status.
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