• 主管部门:
  • 中国科学院
  • 主办单位:
  • 中科院科技战略咨询研究院
  • 出版单位:
  • 世界科学技术杂志社
    科学出版社
  • 主编:
  • 陈凯先
  • 执行主编:
  • 胡镜清 陈士林 叶阳
  • 副主编:
  • (按姓氏笔划排列)王 伟 王 阶 王拥军 王喜军 孔令义 吕文亮 孙晓波 李 萍 李志刚 张卫东 陈立典 果德安 罗国安 赵军宁 徐宏喜 高秀梅 唐旭东 梁繁荣 葛金文
  • 名誉社长:
  • 徐伟宣
  • 社长:
  • 张志华
  • 编辑部主任:
  • 王 瑀
  • 编辑部:
  • 张娜娜 马雅静 方垚 王涵 何岸波 郭嫦娥
  • 责任译审:
  • 王晶
  • 国际刊号:
  • 1876-3553
  • 国内刊号:
  • 11-5699/R
  • 社址:
  • 北京市海淀区中关村东路55号思源楼1203
  • 邮编:
  • 100190
  • 电话:
  • 010-62616352
  • 网址:
  • www.wst.ac.cn
  • E-mail:
  • wst@casipm.ac.cn
  • 海外发行号:
  • M1644
  • 邮刊代号:
  • 2-534

逍遥散治疗抑郁或焦虑的多靶点、多环节机制研究
Present situation and prospect of XiaoyaoSan's antidepressant and anxiety
  
DOI:
中文关键词:  关键词:逍遥散  抑郁症  焦虑症  药效物质基础
英文关键词:Key words: Xiaoyao San  Depression  Anxiety  Pharmacodynamic material basis
基金项目:
作者单位
李晓娟,陈家旭*,周雪明,王亭晔,宋明,侯雅静,王方方 北京中医药大学中医学院北京100029 
摘要点击次数: 327
全文下载次数: 
中文摘要:
      摘要:抑郁症和焦虑症是常见的严重危害人类身心健康的精神疾病。抑郁和焦虑作为一种生物-心理-社会交互致病的疾病,单一、靶向明确的药物很难收到理想的治疗效果。而中复方逍遥散自身的多成分特点,决定了其能够多靶点、多系统、多层次地调节抑郁和焦虑。课题组多年从事对逍遥散抗抑郁和焦虑的基础和临床研究,发现逍遥散具有“双向调节”和“多靶点、多系统、多层次”的两大特征。然而,要搞清楚逍遥散抗抑郁和焦虑的药效物质基础,尚需进一步借助多种学科研究手段,围绕中医证以病证结合为前提,纳入疾病和证候双重评价手段,以脑肠轴为切入点,密切结合方证耦合机制开展研究。
英文摘要:
      Abstract:Depression and anxiety are one of common mental illness that are being seriously harm to human physical and mental health in recent years. Depression and anxiety are difficult to be well treated with a single and targeted drug, owing to its biological-psychological-social interaction pathogenic feature. Due to its own multi-component characteristics, traditional Chinese medicine compound Xiaoyao San could exert the anti-depression and anxiety effects from multi-level, multi-link and multi-target. Based on our group’s previous studies on the effects and mechanism of Xiaoyao San on the anti-depression and anxiety, we proposed that Xiaoyao San had two main characteristics when treating the depression and anxiety that were "two-way adjustment" and "multi-target, muti-system, multi-level". Additionally, to further clarify the pharmacodynamic material basis of Xiaoyao San, more importance is that we should depend on the variety of disciplinary research methods, focused on the TCM syndrome and the combination of disease and TCM syndrome, include the evaluation methods including disease evaluation and syndrome evaluation, emphasize the importance of brain-gut axis, and combine with the correlation between the formula and the syndrome.
查看全文  查看/发表评论  下载PDF阅读器
关闭