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基于数据挖掘研究现代中医治疗阿尔茨海默病用药规律
Study on Medication Law of Modern Chinese Medicine in the Treatment of Alzheimer’s Disease Based on Data Mining
  
DOI:10.11842/wst.2019.07.021
中文关键词:  古今医案云平台(V1.4.1)  阿尔茨海默病  现代中医  用药规律
英文关键词:Ancient and Modern Medical Case Cloud Platform (V1.4.1), Alzheimer􀆳s disease, Modern Chinese medicine, Medication law
基金项目:山东省科技厅重点研发计划资助项目(2017GSF19116):督脉灸疗法治疗阿尔茨海默病的疗效评价研究,负责人:刘源香;山东省科技厅重点研发计划资助项目(2015GSF119020):督脉灸疗法治疗颈动脉粥样硬化的疗效评价研究,负责人:杨继国。
作者单位
宋克立 山东中医药大学第一临床医学院 济南 250014 
张琼琼 山东中医药大学针灸推拿学院 济南 250014 
王晓晗 山东中医药大学中医学院 济南 250014 
刘源香 山东中医药大学 济南 250014 
摘要点击次数: 103
全文下载次数: 137
中文摘要:
      目的 基于“古今医案云平台(V1.4.1)”,对近30年中医治疗阿尔茨海默病(Alzheimer??s disease.AD)的中药处方进行整理分析,挖掘现代中医治疗AD的用药规律。方法 搜集中国知识资源总库(CNKI)、中文科技期刊数据库(重庆维普)、中国学术期刊数据库(万方数据)、中国生物医学文献数据库(CBM)中1988年1月1日-2018年10月1日收录的所有用于治疗AD中药处方,并构建方剂数据库,应用“古今医案云平台(V1.4.1)”系统中的频次分析、药对分析、关联分析、功效分析等方法进行数据挖掘,分析现代中医治疗阿尔茨海默病的用药规律,总结临床经验。结果 对筛选出的214首方剂进行分析,得出使用频次前五位的中药分别为石菖蒲、黄芪、熟地、丹参、茯苓,使用频次位列前三位的中药对分别为“石菖蒲、远志”“石菖蒲、黄芪”“石菖蒲、丹参”,且常用药对皆由高频药物组成。润肠通便为现代临床治疗AD最常用的功效,其次为生津养血、安神益智等。对使用频次大于20的中药聚类得出3组常用药物组方。结论 现代中医治疗AD以补气活血为主要原则,并辅以补肾、化痰开窍、活血化瘀、安神益智类药物。
英文摘要:
      Objective Based on the“Ancient and Modern Medical Case Cloud Platform (V1.4.1)”, to sort out and analyze the prescriptions of traditional Chinese medicine (TCM) for the treatment of Alzheimer’s disease (AD) in recent 30 years, and to explore the medication law of modern Chinese medicine for the treatment of AD. Methods Chinese National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (Chongqing VIP), China Science Periodical Database (Wanfang), and China Biology Medicine disc (CBM) were retrieved for all the TCM prescriptions about AD from January 1, 1988 to October 1, 2018, and formula database was established. Frequency analysis, medicine pair analysis, correlation analysis, effect analysis etc in the“Ancient and Modern Medical Case Cloud Platform (V1.4.1)” were applied for data mining. The medication law of modern Chinese medicine in AD was analyzed, and clinical experience was summarized. Results A total of 214 formulas were analyzed, and according to the use frequency, the top 5 traditional Chinese medicines were Rhizoma Acori Tatarinowii, Radix Astragali, Radix Rehmanniae Praeparata, Radix et Rhizoma Salviae Miltiorrhizae and Poria. The top 3 medicine pairs were“Rhizoma Acori Tatarinowii and Radix Polygalae”,“Rhizoma Acori Tatarinowii and Radix Astragali”and“Rhizoma Acori Tatarinowii and Radix et Rhizoma Salviae Miltiorrhizae”, and the commonly used medicine pairs were all composed of high- frequency medicines. Moistening intestines to relieve constipation was the most frequently used function in modern Chinese medicine for treating AD, followed by promoting fluid production and nourishing blood as well as tranquilizing and boosting intelligence. There were 3 formulae of commonly used medicine groups were obtained by cluster analysis of TCM with the use frequency of more than 20. Conclusion Modern Chinese medicine treatment in AD takes tonifying qi and invigorating blood as the main principle, supplemented by medicines for tonifying kidney, resolving phlegm to open orifices, invigorating blood and resolving phlegm as well as tranquilizing and boosting intelligence.
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